All Italian cities deserve at least a one-day visit, but some more than others. We offer this day trip from Rome to Milan not only because Milan is the European capital of fashion and design: it is also the financial capital of Italy and a treasure trove of history and art. The outstanding cathedral is the most important gothic architectural building in Italy, the “Vittorio Emanuele” Gallery is Milan’s social salon, and there is much more to see! The convent of Santa Maria Delle Grazie hosts Leonardo da Vinci’s most famous fresco, “The Last Supper.” If you are planning a day trip from Rome to Milan, please book a visit to “The Last Supper” well in advance.